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In patients with advanced stage colon cancer (colon and rectum cancer), the spread of cancer cells to the abdominal cavity and the abdominal membrane (peritoneal) covering the organs in the abdominal cavity is called Peritoneal Carcinomatosis (PC).
Which disease HIPEC Treatment is used for?
HIPEC Treatment is a method used in the treatment of Peritoneal Carcinomatosis (Abdominal Cancer).
In patients with advanced stage colon cancer (colon and rectal cancer), the spread of cancer cells into the abdominal cavity (peritoneal) abdominal membrane covering the organs located in the abdominal cavity is called Peritoneal Carcinomatosis (Abdominal Cancer).
When the patient is diagnosed with Peritoneal Carcinomatosis (Abdominal Cancer), it should be evaluated if the disease has affected other areas in the body. If there is no spread in another distant organ in the body before surgery, with the region of the colon cancer along with the region of the abdominal membrane should be removed. The goal is to purify the cancer completely from the body, so there is no cancerous tissue left behind.
This process is called Cytoreduction (SRC). In addition, HIPEC Treatment is applied during surgery to increase the success in overall treatment.
HIPEC Treatment F.A.Q.
- Peritoneal Mesothelioma
- Pseudomixoma Peritonei
- Gastric cancer (clinical trials)
- Colorectal cancer (clinical trials)
- Ovarian carcinoma (clinical trials)
- Allows for higher doses of chemotherapy, in comparison to the intravenous administration
- Enhances and concentrates chemotherapy within the abdomen, where the cancer is located
- Minimizes the rest of the body’s exposure to the chemotherapy
- Improves chemotherapy absorption and susceptibility of cancer cells
- Reduces some chemotherapy side effects
Various chemotherapies are used and there is no clear consensus on which drugs should be used.
Mitomycin C is the most commonly used agent because it was one of the first used drugs for this therapy.
With the advent of platinum based chemotherapeutics, oxaliplatin has started gaining more popularity. Although both have proven similar efficacy so far, some argue that oxaliplatin tends to have better results.
The combination of CRS + HIPEC is an invasive and very aggressive intervention that requires hospitalization and admission to surgical intensive care unit (SICU).
There are specific risks linked to each one of the two treatment steps: during the surgical intervention some complications can in fact occur (15% of cases on average), so that the return to the operating theatre is possible.
In the same way, some reactions to the utilized drug can occur (20% of patients on average). After the CRS + HIPEC intervention, generally one or more cycle of additional systemic intravenous chemotherapy may be necessary.
As already said, this is a complex procedure that requires the intervention of a specialized medical staff and dedicated equipment. For this reason not all centers are able to offer this treatment: if you wish to know which is the nearest center to you, please send us an e-mail.